논문 초록

A small-molecule probe for selective profiling and imaging of monoamine oxidase B activities in models of parkinson's disease
The design of the first dual-purpose activity-based probe of monoamine oxidaseB (MAO-B) is reported. This probe is highly selective towardsMAO-B, even at highMAO-A expression levels, and could sensitively report endogenous MAO-B activities by both in situ proteome profiling and livecell bioimaging. With a built-in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO-B imaging probes failed to do thus far: the live-cell imaging of MAO-B activities without encountering diffusion problems.
닫기